Sermorelin

Sermorelin

Date August 11, 2016 Author By Category Health Information

Sermorelin has definitely been a hot topic as of recent and there is no question why. Sermorelin has shown great promise in multiple research studies and once approved by the FDA, Sermorelin may be used for multiple purposes here in the near future. Sermorelin is a peptide that has been synthesized with specific amino acid sequences to help stimulate the natural secretion of growth hormone, which is in the hypothalamus. Recent research studies have been conducted in order to determine just how useful this peptide may be.checkout other blog posted at http://www.clinicalconnections.info/ifg1-lr3/

Studies conducted by Indian Lake Medical Weight Loss & Wellness in Hendersonville, Tennessee have shown that regular application of sermorelin may have some very promising results. One of these promising areas happens to be sleep quality.

Due to the fact that the body produces most of its HGH during deep sleep, the levels of HGH that you have are determined by your quality of sleep. However, sermorelin therapy has been shown to promote longer, deeper sleeping patters, which therefore produces more HGH secretion.

Another study conducted by the International Study for Applied Research in Aging, has shown that sermorelin can extend the life of those who suffer from pathogenic GHD (Growth Hormone Deficiency) and can also reduce the effects of intrinsic disease.

However, even though these results are quite promising, the amount of testing that has been done with sermorelin is still quite minimal. In fact, we still don’t really know what long-term effects sermorelin may have. This is why this popular peptide is still haunted by medical and legal issues and is not yet approved by the FDA for human use. More research is needed to uncover just how useful this peptide may be.

Bruce, Jasen. “What is Sermorelin?” Defy Medical. Web. 15 July 2016.

“Sermorelin & GHRP-6” Indian Lake Medical Weight Loss & Wellness. n.d. Web. 2016 July 25.

Walker, Richer F. “Sermorelin: A Better Approach to Management of Adult-Onset Growth Hormone Insufficiency?” Dove Medical Press. 2006 Dec. Web. 2016 July 25.… Read the rest...

Read More

IFG1-LR3

Date August 11, 2016 Author By Category Health Information

IFG1-LR3 is a popular polypeptide that possesses many of the same qualities as the well-known substance, insulin. As a matter of fact, IGF stands for insulin-like-growth factor. IFG1-LR3 is particularly famous for the effects that it has on bone growth.

There have been a multitude of studies involving IFG1-LR3 and they have been pretty promising. In fact, a study conducted by King’s College in London has shown how interactions between circulating and local IGf-I expression may very well play a crucial role in regulating muscle mass. This discovery is especially helpful in researching for those who suffer from GH deficiency.visit this latest articles for additional tips.

Another study conducted by the Venetian Institute of Molecular Medicine has shown even more evidence in support of the regulation of skeletal muscle growth. They have determined that a signaling pathway involving IFG1-LR3 and intracellular components like protein kinase B play a major role in regulating muscle growth. This pathway is vital for muscle growth and regeneration. However, it’s role in adult muscle response to mechanical load has yet to be determined.

Just like many other substances of this type, there is still a lot that we do not know about IFG1-LR3. Although this polypeptide shows some promising effects, it is still unclear what kind of side-effects may come along as well. Only more studies and more research will determine the use and regulation of IFG1-LR3.

Schiaffino, Stefano and Cristina Mammucari. “Regulation of Skeletal Muscle Growth by the IFG1-Akt/PKB Pathway: Insights from Genetic Models.” BioMed Central. 2011 January 24. Web. 2016 July 25.
Star, Russian. “IFG1-LR3 the Anabolic Powerhouse.” Evolutionary. Web. 19 July 2016.

Velloso, C.P. “Regulation of Muscle Mass by Growth Hormone IFG1” U.S. Library of Medicine National Institutes of Health. 2008 June. Web. 2016 July 25.… Read the rest...

Read More

CJC-1295

Date August 11, 2016 Author By Category Health Information

CJC-1295 is also known as DAC:GRF, which is short for drug affinity complex: growth hormone-releasing factor. It is a synthetic analogue of GHRH and a growth hormone secretagogue. CJC-1295 is known for increasing the plasma growth hormone known as GH as well as IGF-1.visit this link for more details.

Studies conducted by the Karolinska Institutet in Stockholm, Sweden has shown some great results in the application of CJC-1295. These studies have shown that CJC-1295 has the ability to increase growth hormone as well as IGF-1 secretions. Therefore, CJC-1295 has also shown to increase the benefits that goes along with this as well. These studies have also shown that application of CJC-1295 can maintain a steady increase of these substances.

Other studies, like the one conducted by Portland State University, has shown that CJC-1295 can also double the half-life and bioavailability of growth hormone-releasing hormone and stimulate IGF-1. It has also been shown to increase the half-life of acting agents by bioconjugation.

CJC-12-95 has also been involved in the investigation of the treatment of lipodystrophy as well as growth hormone deficiency. However, the further experimentation in this area was discontinued due to the death of one of the trial subjects. These studies were conducted by the University of Olso.

The question of how safe CJC-1295 has yet to be determined, despite all of the research that has already been conducted. Due to results of previous trials, scientists are treading lightly with this substance and research may possibly be slow-going at this point. However, this research is vital in determining how this substance can be utilized in the future.

Andersen Hartvig, Rune; Bjerre Holm, Niels; Weihe Dalsgaard, Petur; Ask Reitzel, Lotte; Breum Müller, Irene; Linnet, Kristian (2014). “Identification of peptide and protein doping related drug compounds confiscated in Denmark between 2007-2013”. Scandinavian Journal of Forensic Science 20 (2). doi:10.2478/sjfs-2014-0003.ISSN 2353-0707.
“Current Research Findings Regarding CJC-1295”. Neo Scientific.

Retrieved 3 August 2015. The reason why CJC1295 possesses the ability to lengthen the half-life within the active agent has to do with the scientific process known as bioconjugation. This technology, which is relatively new in nature, is defined by its ability to take a reactive group and bond it to a peptide (Aslam and Dent). This attachment causes a reaction with a nucleophilic unit; a typically partially molecule that is found within the bloodstream of an animal test subject.

This reaction in turn causes a more stable bond to occur. This specific peptide has an especially high attraction to albumin, a globular protein that is soluble in water. This affinity prohibits natural degradation, which in turn increases the peptide’s half-life (Hermanson). Additionally, clinical research performed on animal test subjects has thus far shown that there have been no signs of DPP-IV degradation present when CJC-1295 was introduced (Gonzalez, US Peptide Articles).

Jetté, Lucie; Léger, Roger; Thibaudeau, Karen; Benquet, Corinne; Robitaille, Martin; Pellerin, Isabelle; Paradis, Véronique; van Wyk, Pieter; Pham, Khan; Bridon, Dominique P. (2005). “Human Growth Hormone-Releasing Factor (hGRF)1–29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats: Identification of CJC-1295 as a Long-Lasting GRF Analog”(PDF). Endocrinology 146 (7): 3052–3058.doi:10.1210/en.2004-1286. ISSN 0013-7227.PMID 15817669.

Peptide Sciences. “CJC-1295 DAC 5mg.” Highly Purified Peptides. n.d. Web. 2016 July 25.… Read the rest...

Read More